METHOD FOR DETERMINING THE AMOUNT OF CONJUGATED TAXANE IN POLYGLUT ACID-TAXANE CONJUGATES

The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): R1R2N-NH2 (I), wherein R1 and R2 are as defined in the description; to give...

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Bibliographic Details
Main Authors HOVDA KEITH, FAZIONI STEFANO, SIVIERO LUIGI, MCKENNON MARC, SPOONEMORE HOLLY, LIVI VALERIA
Format Patent
LanguageEnglish
Published 17.06.2010
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate said method comprising: a) reacting the PGA-taxane conjugate with a compound formula (I): R1R2N-NH2 (I), wherein R1 and R2 are as defined in the description; to give a unbound taxane and a PGA hydrazide and b) determining the amount of unbound taxane.
Bibliography:Application Number: US20090529762