NOVEL POLYNITROGENATED SYSTEMS AS ANTI-HIV AGENTS

The present invention describes the synthesis of the compounds of formulae (1), (2) and (3) in which m and n, which may be identical or different, may have the values 0, 2, 3, 4, 5 and 6; Z and Y, which may be identical or different, represent a nitrogenated cyclic system bonded by nitrogen or by on...

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Main Authors PETTERSSON SALOM SOFIA, BORRELL BILBAO JOSE IGNACIO, PUIG DE LA BELLACASA RALMON, RABAL GRACIA MARIA OBDULIA, PEREZ NUENO VIOLATA, BATLLORI AGUILA XAVIER, ROS BLANCO LAIA, TEIXIDO CLOSA JORDI, ESTE ARAQUE JOSE, ARMAND UGON MERCEDES, NONELL MARRUGAT SANTIAGO, CLOTET CODINA IMMA
Format Patent
LanguageEnglish
Published 28.01.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention describes the synthesis of the compounds of formulae (1), (2) and (3) in which m and n, which may be identical or different, may have the values 0, 2, 3, 4, 5 and 6; Z and Y, which may be identical or different, represent a nitrogenated cyclic system bonded by nitrogen or by one of the ring carbons or an NR1R2 system; and X is selected from the group consisting of hydrogen, C1-C12 alkyl, substituted alkyl, C3-C12 aryl, amino, alkylamino, nitro, hydroxy, alkoxy, halogen, carboxy or carboxamido. The use of the compounds of formulae (1), (2) and (3) as anti-HIV agents in the treatment of Acquired Immune Deficiency Syndrome (AIDS) is described.
Bibliography:Application Number: US20070447409