Method of Enhancing Remyelination in Demyelinating Diseases of the Central Nervous System
The present invention provides methods for enhancing remyelination or decreasing or inhibiting demyelination in central nervous system (CNS) of a mammalian subject by administering to the subject an effective amount of a Semliki Forest Virus (SFV) epitope E2 137-151 peptide together with a pharmaceu...
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Main Author | |
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Format | Patent |
Language | English |
Published |
17.12.2009
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides methods for enhancing remyelination or decreasing or inhibiting demyelination in central nervous system (CNS) of a mammalian subject by administering to the subject an effective amount of a Semliki Forest Virus (SFV) epitope E2 137-151 peptide together with a pharmaceutically acceptable carrier, or an antibody to E2 137-151 peptide ("E2 137-151 antibody"). The present invention also provides a method for treating a CNS disease, particularly, multiple sclerosis (MS), in a mammalian subject by administering to the subject a therapeutically effective amount of an E2 137-151 peptide together with a pharmaceutically acceptable carrier, or an anti E2 137-151 antibody. A polyclonal and a monoclonal E2 137-151 antibody are also provided by the present invention. |
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Bibliography: | Application Number: US20090429670 |