PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS

The present invention is directed to a process for preparing alpha,alpha disubstituted gamma-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain...

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Bibliographic Details
Main Authors WALLACE DEBRA, CAMPOS KEVIN R, KOHMURA YOSHINORI, KATO SHINJI, YASUDA NOBUYOSHI, POLLARD DAVID J, ISHIBASHI HIDEAKI, KLAPARS ARTIS, TAKEZAWA AKIHIRO, CHEN CHENG, WALDMAN JACOB H
Format Patent
LanguageEnglish
Published 01.10.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention is directed to a process for preparing alpha,alpha disubstituted gamma-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
Bibliography:Application Number: US20070309999