5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibitin...

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Main Authors PENNING THOMAS D, LI BIQIN, MACK HELMUT, KALVIN DOUGLAS M, GRACIAS VIJAYA J, HOBSON ADRIAN D, TEUSCH NICOLE, GASIECKI ALAN F, SHUAI QI, VASUDEVAN ANIL, SARRIS KATHY A, GEORGE DAWN, MOORE N. ST. JOHN, PATEL JYOTI R, JOHNSON ERIC F, AKRITOPOULOU-ZANZE IRINI, LONG ANDREW J, WOODS KEITH W, WAKEFIELD BRIAN D, TURNER SEAN C, BAKKER MARGARETHA H.M, WANG LU, SWANN, JR. STEVEN L, MICHMERHUIZEN MELISSA J, MIYASHIRO JULIE M, KOVAR PETER J, DJURIC STEVAN W
Format Patent
LanguageEnglish
Published 13.08.2009
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.
Bibliography:Application Number: US20080327991