Fc VARIANTS WITH ALTERED BINDING TO FcRn

The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

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Bibliographic Details
Main Authors DESJARLAIS JOHN R, KARKI SHER BAHADUR, CHAMBERLAIN AARON KEITH, LAZAR GREGORY ALAN, DAHIYAT BASSIL I
Format Patent
LanguageEnglish
Published 25.06.2009
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
Bibliography:Application Number: US20080341769