Prevention or Treatment of Cancer Using Integrin alphavbeta3 Antagonists in Combination with Other Agents

• Main Authors: KIENER PETER, WALSH WILLIAM, DORMITZER MELISSA, WOESSNER RICHARD, HEINRICHS JON
• Format: Patent
• Language: English
• Published: 11.06.2009
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective amount of one or more antagonists of Integrin alphaVbeta3 alone or in combination with the administration of an effective amount of one or more other agents useful for cancer therapy. The invention also provides pharmaceutical compositions comprising one or more antagonists of Integrin alphaVbeta3 and/or one or more other agents useful for cancer therapy. In particular, the invention is directed to methods of treatment and prevention of cancer by the administration of a therapeutically or prophylactically effective amount of one or more antagonists of Integrin alphaVbeta3 alone or in combination with standard and experimental therapies for treatment or prevention of cancer. Also included are methods for screening for epitope-specific Integrin alphaVbeta3 antagonists which can be used according to the methods of the invention. In addition, methods for facilitating the use of Integrin alphaVbeta3 antagonists in the analysis of Integrin alphaVbeta3 expression in biopsies of animal model and clinical study samples are also contemplated.