Aryl and Heteroaryl Compounds, Compositions, Methods of Use

This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. Formula (X) wherein R102 is selected fro...

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Bibliographic Details
Main Authors GOHIMMUKKULA DEVI REDDY, TYAGI SAMEER, MJALLI ADNAN M.M
Format Patent
LanguageEnglish
Published 14.05.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be used to inhibit the intrinsic pathway of blood coagulation. Formula (X) wherein R102 is selected from the group consisting of -C(O)OH, -C(O)OCH3, -C(O)O-t-butyl, -C(O)NH-OCH2-phenyl, C(O)NHOH, and -C(O)NHSO2CH3; and wherein R101, R103, R104 and Y are as defined herein.
Bibliography:Application Number: US20060884595