Diurea derivatives

The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro-inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a med...

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Bibliographic Details
Main Authors PETTERSSON LARS OLOF GORAN, ABRAMO AINA LISBETH, SUNDSTEDT ASA ANETTE, ANDERSSON KERSTIN INGALILL
Format Patent
LanguageEnglish
Published 07.05.2009
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Summary:The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro-inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a medicament, the use of said compound for the manufacturing of a medicament for the treatment of immune disorders which benefit from inhibition of production of IL-2 and other pro-inflammatory cytokines and/or induction of apoptosis in activated T-cells, a pharmaceutical composition comprising said compound and a method of treatment comprising administration of a pharmaceutically effective amount of said compound.
Bibliography:Application Number: US20050585054