Novel compounds that are ERK inhibitors

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein....

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Main Authors ZHU HUGH Y, WU YIJI, MADISON VINCENT S, KELLY JOSEPH M, DENG YONGQI, WANG JAMES J-S, ALHASSAN ABDUL-BASIT, DOLL RONALD J, HRUZA ALAN W, ZHU LIANG, SHIPPS, JR. GERALD W, DONG YOUHAO, XIAO LI, GAO XIAOLEI, TSUI HONUNG, SUN ROBERT, BOGA SOBHANA BABU, SAMATAR AHMED A, NAN YANG, WANG TONG, PALIWAL SUNIL, CELEBI AZIM ALAN, DESAI JAGDISH A, SHIH NENG-YANG, COOPER ALAN B, SIDDIQUI M. ARSHAD, PATEL MEHUL
Format Patent
LanguageEnglish
Published 07.05.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
Bibliography:Application Number: US20070810282