Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5- tert-butyl-2-methoxybenzyl)quinuclidin-3-amine

This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter "compound of Formula I") and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis...

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Bibliographic Details
Main Authors BASFORD PATRICIA A, POST RONALD J, TABER GERALDINE P, SMITH JULINA D
Format Patent
LanguageEnglish
Published 16.04.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention relates to an improved process for the preparation of (2S,3S)-2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter "compound of Formula I") and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (Ia).
Bibliography:Application Number: US20050588049