AMINODIHYDROTHIAZINE DERIVATIVES

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R...

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Main Authors SAKAGUCHI GAKU, SUZUKI SHINJI, ITOH NAOHIRO, YUKIMASA AKIRA, KORIYAMA YUJI, UEDA KAZUO, HARAGUCHI HIDEKAZU, YASUI KEN, HORI AKIHIRO, KATO AKIRA, KANDA YASUHIKO, KOBAYASHI NAOTAKE
Format Patent
LanguageEnglish
Published 26.03.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
Bibliography:Application Number: US20060089409