Use Of Sucrose To Suppress Mannitol-Induced Protein Aggregation

The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannito...

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Bibliographic Details
Main Authors LUISI DONNA L, HO KIN, KANTOR ANGELA, WARNE NICHOLAS W, SEK DAVID C
Format Patent
LanguageEnglish
Published 21.08.2008
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.
Bibliography:Application Number: US20080032490