Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.

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Bibliographic Details
Main Authors PICKENS JASON C, CHUCHOLOWSKI ALEXANDER, THIRUVAZHI MOHAN SANTHANAM, ANIKIN ALEXEY, ZHU TONG, MCGRATH DOUGLAS ERIC, MIKEL CHARLES, KADUSHKIN ALEXANDER, ZOZULYA SERGEY, LIU YAHUA, YAN ZHENG, JIANG LUYONG, MCGEE DANNY PETER CLAUDE, GREGOR VLAD E, VAIRAGOUNDAR RAJENDRAN, GANTLA VIDYASAGAR REDDY, VAVILALA GOVERDHAN REDDY, WEBB THOMAS
Format Patent
LanguageEnglish
Published 17.07.2008
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.
Bibliography:Application Number: US20070891604