RHO KINASE INHIBITORS

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compos...

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Main Authors WU FRANK, HICKEY EUGENE RICHARD, PROKOPOWICZ ANTHONY S, SHIH CHENG-KON, BOSANAC TODD, YOUNG ERICK RICHARD, KIRRANE THOMAS MARTIN, GINN JOHN DAVID, LIU WEIMIN, SCHLYER SABINE K, SNOW ROGER JOHN, TURNER MICHAEL ROBERT
Format Patent
LanguageEnglish
Published 03.07.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.
Bibliography:Application Number: US20070856740