Microgravity bioreactor systems for production of bioactive compounds and biological macromolecules

• Main Authors: VALLURI JAGAN V, GONDA STEVEN R
• Format: Patent
• Language: English
• Published: 12.06.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to compositions and methods of plant, fungal and bacterial cell culture that can be effectively utilized for three-dimensional plant, fungal, and bacterial cell growth and production of bioactive compounds of interest. The culture methods employ a microgravity environment such that rapid establishment and expansion of cells into tissue constructs occurs influencing expression of biological macromolecules and biopharmaceuticals. The present invention is further directed to a method for the in vitro cultivation of plant, fungal, and bacterial cells in a liquid nutrient medium in modeled microgravity with potential for large scale manipulations.