Method for the Preparation of Oxime, Thiazolidine, Dithiane, Dithiolane, or Hydrazone Linked Analogues of Growth Hormone

A method for the production of conjugated growth hormone is provided, wherein a GH derived aldehyde or ketone is reacted with an alkoxyamine, hydrazine or 2-aminothiol compound at acid pH in the presence of a dipolar solvent.

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Bibliographic Details
Main Authors DORWALD FLORENCIO ZARAGOZA, SCHIODT CHRISTINE BRUUN
Format Patent
LanguageEnglish
Published 27.03.2008
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Summary:A method for the production of conjugated growth hormone is provided, wherein a GH derived aldehyde or ketone is reacted with an alkoxyamine, hydrazine or 2-aminothiol compound at acid pH in the presence of a dipolar solvent.
Bibliography:Application Number: US20050577213