Piperidine Derivative or Pharmaceutically Acceptable Salt Thereof

The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (-R1) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [-C(-O)-R4], or a pharmaceutically acceptable salt thereof...

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Main Authors KIKUCHI KAZUMI, TOKUZAKI KAZUO, NAGAKURA YUKINORI, TOMIYAMA HIROSHI, WATANABE TOSHIHIRO, FUJIYASU JIRO, SONEGAWA MOTOHARU, IWAI YOSHINORI
Format Patent
LanguageEnglish
Published 20.03.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The piperidine derivative of the present invention in which the 4-position of the piperidine ring is bonded, via vinylene, to a mono-substituted (-R1) or unsubstituted benzene ring and the 1-position of the piperidine ring has an acyl group [-C(-O)-R4], or a pharmaceutically acceptable salt thereof has an excellent sodium channel inhibition action and an excellent analgesic action and shows a high analgesic effect particularly to neurogenic pain. The present compound is useful as a sodium channel inhibitor of low side effect
Bibliography:Application Number: US20050661446