Process for the Preparation of Telithromycin

The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts Formula I The novel compounds (i) 10,11-Anhydro-2',4''-di-O-benzoyl-12-O-imidazolylcarbonyl-6-O-methylerythromycin A of formula (Xa) Formula (Xa) (ii)...

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Bibliographic Details
Main Authors SOHANI SUHAS, DEODHAR MANDAR, DAVADRA MAHESH, PATEL MANISH, KANSAL VINODHAMAR, PATEL NISHANT
Format Patent
LanguageEnglish
Published 08.11.2007
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present invention relates to the process for the preparation of compounds of formula (I) or its pharmaceutically acceptable salts Formula I The novel compounds (i) 10,11-Anhydro-2',4''-di-O-benzoyl-12-O-imidazolylcarbonyl-6-O-methylerythromycin A of formula (Xa) Formula (Xa) (ii) 2',4''-di-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-6-O-methylerythromycin A 11,12-cyclic carbamate of formula (XIa) Formula (XIa) (iii) 2'-O-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O-desosaminyl-6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) Formula (XIIa) (iv) 2'-benzoyl-11-amino-11-N-[4-[4-(3-pyridyl)imidazol-1-yl]butyl]-11-deoxy-5-O-desosaminyl-6-O-methylerythronolide A 11,12-cyclic carbamate of formula (XIIa) Formula (XIIa) and their use as intermediates in formation of compound of Formula I. Also the process of preparation of compound of formula (XIIIa). Formula (XIIIa)
Bibliography:Application Number: US20050591889