Method of Crystallization of Bicalutamide

The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 mum of Dp10, 10 to 25 mum of Dp50 and 25 to 100 mum of Dp90, and t...

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Bibliographic Details
Main Authors ITAYA NOBUSHIGE, KATSURA TADASHI, MIZUNO TADASHI
Format Patent
LanguageEnglish
Published 11.10.2007
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 mum of Dp10, 10 to 25 mum of Dp50 and 25 to 100 mum of Dp90, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 mum of Dp10, 2 to 5 mum of Dp50 and 5 to 15 mum of Dp90.
Bibliography:Application Number: US20050571956