Novel compounds that are ERK inhibitors

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also di...

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Main Authors DESAI JAGDISH, SAMATAR AHMED A, WU YIJI, SHIPPS GERALD W.JR, KELLY JOSEPH M, DENG YONGQI, NAN YANG, WANG TONG, PALIWAL SUNIL, SIDDIQUI M. A, DOLL RONALD, SHIH NENG-YANG, WANG JAMES J, HRUZA ALAN W, MADISON VINCENT, DONG YOUHAO, BOGA SOBHANA B, XIAO LI, ZHU HUGH, COOPER ALAN, TSUI HONUNG, SUN ROBERT, CELEBI AZIM A
Format Patent
LanguageEnglish
Published 16.08.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
AbstractList Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
Author DESAI JAGDISH
SIDDIQUI M. A
SAMATAR AHMED A
COOPER ALAN
SHIPPS GERALD W.JR
BOGA SOBHANA B
SUN ROBERT
KELLY JOSEPH M
WU YIJI
HRUZA ALAN W
DONG YOUHAO
XIAO LI
DENG YONGQI
NAN YANG
MADISON VINCENT
SHIH NENG-YANG
WANG JAMES J
WANG TONG
DOLL RONALD
ZHU HUGH
PALIWAL SUNIL
CELEBI AZIM A
TSUI HONUNG
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– fullname: WANG TONG
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– fullname: SIDDIQUI M. A
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– fullname: SHIH NENG-YANG
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– fullname: HRUZA ALAN W
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– fullname: XIAO LI
– fullname: ZHU HUGH
– fullname: COOPER ALAN
– fullname: TSUI HONUNG
– fullname: SUN ROBERT
– fullname: CELEBI AZIM A
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Snippet Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title Novel compounds that are ERK inhibitors
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