METHOD, SYSTEM AND, COMPUTER SOFTWARE FOR EFFICIENT UPDATE OF PROBE ARRAY ANNOTATION DATA

• Main Authors: SHIGETA RONALD T, LAI BENJAMIN, TRACY ADAM N, VALMEEKAM VENU, TRUTANE STEPHEN C
• Format: Patent
• Language: English
• Published: 14.06.2007
• Subjects: BEER; BIOCHEMISTRY; CALCULATING; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPUTING; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; COUNTING; ELECTRIC DIGITAL DATA PROCESSING; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

In one embodiment, a method of assigning transcripts to probe sets is described that comprises retrieving one or more data sets from one or more sources; generating one or more clusters using transcript data from the data sets; aligning one or more probe sequences to a representative sequence from one or more of the clusters; aligning the representative sequence to a genome sequence, wherein the genome sequence is annotated with probe location information; mapping the aligned probe sequences to the genome sequence using the alignment of the representative sequence and genome sequence; and computing a score using a number associated with the aligned probe sequences and a number associated with the probe location formation associated with a region of the genome sequence that corresponds to the aligned representative sequence.