Vitamin d receptor modulators

The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1alpha,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

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Bibliographic Details
Main Authors MA TIANWEI, JONES CHARLES D, NAGPAL SUNIL, GAJEWSKI ROBERT P, LU JIANLIANG, YEE YING K, LINEBARGER JARED H
Format Patent
LanguageEnglish
Published 28.12.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1alpha,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
Bibliography:Application Number: US20060577967