Tnf-alpha binding molecules
The present invention relates to TNF-alpha binding molecules and nucleic acid sequences encoding TNF-alpha binding molecules. In particular, the present invention relates to TNF-alpha binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to huma...
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Main Authors | , , , |
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Format | Patent |
Language | English |
Published |
30.11.2006
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to TNF-alpha binding molecules and nucleic acid sequences encoding TNF-alpha binding molecules. In particular, the present invention relates to TNF-alpha binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-alpha and that are capable of neutralizing TNF-alpha at low concentrations. Preferably, the TNF-alpha binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks). |
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Bibliography: | Application Number: US20050541260 |