Pyrroles substituted by oligonucleotides

• Main Authors: LAURENT ALAIN, MANDRAND BERNARD, CHAIX CAROLE, ZSOLDOS DANIELA, SPINELLI NICOLAS
• Format: Patent
• Language: English
• Published: 24.08.2006
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SUGARS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sampe. (I) wherein R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from -(CH2)-O-, -(CH2)PO-[(CH2)2-O]q-, -(CH2)r; -CO-NR-(CH2)r-0-, -CH2r-NCH3-(CH2)r-O-, -CH2)rCO-NR'-[CH2)2-O]s-, -(CH2)rNCH3[(CH2)2-O]S-, R' is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r' is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r' and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.