Chloromethylation of thiophene

The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). C...

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Main Authors PARKANYI ZSOLT, UGRICS JOZSEF, ARADI MATYAS, GYONGYOSI ISTVAN, KOVACS FERENC, MATENE TOROK ERIKA, BAKOS FERENC, SUPIC ATTILA, SZALAY ERZSEBET, SCHULTZ LASZLO, SZABOM SANDOR, ZSIGA JOZSEF, MAJOR ANDREA, DOMBRADY ZSOLT, GAJARY ANTAL
Format Patent
LanguageEnglish
Published 20.07.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The process according to the invention relates to the preparation of 2-chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II). Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.
Bibliography:Application Number: US20040478238