Stabilized interferon compositions

Stabilized pharmaceutical formulations comprising IFN-beta and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-beta adducts in comparison with IFN-beta formulated with mannitol that has not been highly purified. Methods...

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Bibliographic Details
Main Authors HORA MANINDER S, WOLFE SIDNEY N
Format Patent
LanguageEnglish
Published 12.01.2006
Subjects
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Stabilized pharmaceutical formulations comprising IFN-beta and highly purified mannitol are provided. The highly purified mannitol stabilizes the compositions by reducing the formation of IFN-beta adducts in comparison with IFN-beta formulated with mannitol that has not been highly purified. Methods for increasing the stability of IFN-beta or a variant thereof in a liquid or lyophilized composition and for increasing storage stability of such a composition are also provided.
Bibliography:Application Number: US20050188257