Screening method and device, and new drug screening method and device

The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of an objective lens is chang...

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Bibliographic Details
Main Authors SUZUKI TOSHIYUKI, AKIYAMA TAKASHI, MIKURIYA KENTA, UCHIDA ISAO, IINO TOSHIO
Format Patent
LanguageEnglish
Published 29.12.2005
Edition7
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:The present invention realizes a screening method and device able to obtain the entire image of a cell as a detailed and accurate (with a good SN ratio) image at high speed by observing the cell image while a Nipkow system confocal scanner is used and the focal position of an objective lens is changed in the optical axis direction. In the present invention, a reagent and a fluorescent marked cell are injected into a well. The focal position is changed in the optical axis direction by using the Nipkow system confocal scanner. Excitation light is irradiated to the well in each focal position, and fluorescent light generated from the cell is received and the degree of activity, and so on, of the cell is measured and displayed on the basis of a slice image of the cell.
Bibliography:Application Number: US20050200143