Helix mimetics and composition and methods related thereto

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, R1 and R2 are as defined herein. Such compounds have utility over a wi...

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Bibliographic Details
Main Authors LEE MIN S, EGUCHI MASAKATSU, URBAN JAN, NAKANISHI HIROSHI, MATHEW JESSYMOL, HUBER VINCENT
Format Patent
LanguageEnglish
Published 06.10.2005
Edition7
Subjects
CHEMISTRY
COMBINATORIAL CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, R1 and R2 are as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening such libraries to identify biologically active members.
Bibliography:Application Number: US20050121337