Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

• Main Authors: REEL JON K, DROSTE JAMES J, BRITTON THOMAS C, HENRY STEVEN S, CWI CYNTHIA L, WU JING, AUDIA JAMES A, MABRY THOMAS E, STUCKY RUSSELL D, TUNG JAY S, PORTER WARREN J, THORSETT EUGENE D, LATIMER LEE H, PLEISS MICHAEL A, NEITZ R. J, DRESSMAN BRUCE A, NISSEN JEFFREY S, MCDANIEL STACEY L, JOHN VARGHESE, FREEDMAN STEPHEN, SCOTT WILLIAM L
• Format: Patent
• Language: English
• Published: 15.09.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.