Process monitoring and particle characterization with ultrasonic backscattering

A fermention process is monitored by detecting ultrasound backscattered from the cells as a function of time. A transducer 46 is placed in a fermentor 30 and transmits ultrasound towards a reflecting surface 50 . The transducer receives that portion of the ultrasound which reflects from the reflecti...

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Bibliographic Details
Main Authors PANETTA PAUL D, TUCKER BRIAN J, PAPPAS RICHARD A
Format Patent
LanguageEnglish
Published 14.07.2005
Edition7
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:A fermention process is monitored by detecting ultrasound backscattered from the cells as a function of time. A transducer 46 is placed in a fermentor 30 and transmits ultrasound towards a reflecting surface 50 . The transducer receives that portion of the ultrasound which reflects from the reflecting surface 50 , as well as that portion of the ultrasound which backscatters from cells 34 between the transducer 46 and the reflecting surface 50 . Signals from the transducer are conditioned and subsequently processed to provide output to a controller regarding the status of the fermentation process in real time. The backscattering measurements can be used to determine a growth phase transition, such as the transition between the logarithmic growth phase of the cells and their stationary phase.
Bibliography:Application Number: US20040757734