Condensed heterocyclic compounds

A condensed heterocyclic compound having poly(adenosine 5'-diphospho-ribose)polymerase (PARP) inhibitory activity by the formula (I): wherein R is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, pyri...

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Bibliographic Details
Main Authors KIDO YOSHIYUKI, HATTORI KOUJI, ISHIDA JUNYA, YAMAMOTO HIROFUMI
Format Patent
LanguageEnglish
Published 14.04.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A condensed heterocyclic compound having poly(adenosine 5'-diphospho-ribose)polymerase (PARP) inhibitory activity by the formula (I): wherein R is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, pyridine ring, etc, -Y =Y - is formula (II) wherein L , L , L and L is (1) lower alkylene, (2) lower alkenylene, etc, and R , R , R and R is (1) cyclic amino group, which is substituted with phenyl optionally substituted with one or more suitable substituent(s), etc. provided that when A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, then -Y =Y - is formula (III) or its prodrug, or their salts.
Bibliography:Application Number: US20040501334