Methods and compositions for inhibiting narrowing in mammalian vascular pathways

• Main Author: TREMBLE PATRICE
• Format: Patent
• Language: English
• Published: 02.12.2004
• Edition: 7
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

Methods and related compositions for treating vascular occlusions and preventing vascular narrowing are disclosed. In one embodiment an implantable medical device is provided with a coating comprising at least one cell growth inhibiting ubiquitin activator. In another embodiment a micro syringe is provided that injects the cell growth inhibiting ubiquitin activator directly into the adventitia. One specific embodiment includes a vascular stent having a cell growth inhibiting ubiquitin activator, specifically, hypothemycin.