Screening assays for targets and drugs useful in treatment and prevention of lipid metabolism disorders

The invention relates to the use of C. elegans as a model for identifying genes that are involved in lipid or lipoprotein metabolism and which can serve as drug targets. The invention also provides a system for screening drugs useful in the treatment and prevention of diseases associated with undesi...

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Bibliographic Details
Main Authors HEKIMI SIEGFRIED, BRANICKY ROBYN, SHIBATA YUKIMASA
Format Patent
LanguageEnglish
Published 28.10.2004
Edition7
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention relates to the use of C. elegans as a model for identifying genes that are involved in lipid or lipoprotein metabolism and which can serve as drug targets. The invention also provides a system for screening drugs useful in the treatment and prevention of diseases associated with undesirable or abnormal levels of lipids (e.g., cholesterol) or lipoproteins (e.g., LDL), such as cardiovascular disorders and dyslipidemia.
Bibliography:Application Number: US20040800333