Amide and ester matrix metalloproteinase inhibitors

This invention provides compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein G , Q, D, and G are as defined above for Formula I. Compounds of Formula I, or a pharmaceutically acceptable salt thereof, are inhibitors of MMP-13. The compounds are useful for treating diseases me...

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Bibliographic Details
Main Authors PICARD JOSEPH ARMAND, BUNKER AMY MAE
Format Patent
LanguageEnglish
Published 22.07.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein G , Q, D, and G are as defined above for Formula I. Compounds of Formula I, or a pharmaceutically acceptable salt thereof, are inhibitors of MMP-13. The compounds are useful for treating diseases mediated by MMP-13, including the diseases recited herein such as breast cancer, cartilage damage, rheumatoid arthritis, and osteoarthritis.
Bibliography:Application Number: US20030739261