Oestrogen fatty acid monoester as a hypolipidaemic and antidiabetic agent
Oleoyl estrone or estrone monooleate is a fatty-acid monoester of an estrogen which appear to be useful for the preparation of a medicament for the treatment and/or profilaxis of a human suffering from a metabolic disease selected from the group consisting of diabetes mellitus type 2, hyperlipidemia...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
15.07.2004
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Oleoyl estrone or estrone monooleate is a fatty-acid monoester of an estrogen which appear to be useful for the preparation of a medicament for the treatment and/or profilaxis of a human suffering from a metabolic disease selected from the group consisting of diabetes mellitus type 2, hyperlipidemia (hypertriacylglyceridemia, hyperlipoproteinemia, hypercholesterolemia) and the Metabolic Syndrome X associated with glucose intolerance, hyperinsulinemia, or insulin resistance. Compared with insulin, oleoyl-estrone has the advantage of being aministered orally. The effectiveness of oleoyl-estrone as oral antidiabetic is conspicuous since it does not act as a simple hypoglycemic agent, but goes to the root of the problem lowering insulin resistance. The additional hypolipemic effect allows to extend its use for the treatment of dislipemias. |
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Bibliography: | Application Number: US20040473068 |