Oestrogen fatty acid monoester as a hypolipidaemic and antidiabetic agent

Oleoyl estrone or estrone monooleate is a fatty-acid monoester of an estrogen which appear to be useful for the preparation of a medicament for the treatment and/or profilaxis of a human suffering from a metabolic disease selected from the group consisting of diabetes mellitus type 2, hyperlipidemia...

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Main Authors FERNANDEZ LOPEZ JOSE ANTONIO, LAMANA MARIANO ALEMANY, REMESAR BETLLOCH FRANCISCO JAVIER
Format Patent
LanguageEnglish
Published 15.07.2004
Edition7
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:Oleoyl estrone or estrone monooleate is a fatty-acid monoester of an estrogen which appear to be useful for the preparation of a medicament for the treatment and/or profilaxis of a human suffering from a metabolic disease selected from the group consisting of diabetes mellitus type 2, hyperlipidemia (hypertriacylglyceridemia, hyperlipoproteinemia, hypercholesterolemia) and the Metabolic Syndrome X associated with glucose intolerance, hyperinsulinemia, or insulin resistance. Compared with insulin, oleoyl-estrone has the advantage of being aministered orally. The effectiveness of oleoyl-estrone as oral antidiabetic is conspicuous since it does not act as a simple hypoglycemic agent, but goes to the root of the problem lowering insulin resistance. The additional hypolipemic effect allows to extend its use for the treatment of dislipemias.
Bibliography:Application Number: US20040473068