Benzimidazole quinolinones and uses thereof

Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Stru...

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Main Authors HARRISON STEPHEN D, MCCREA WILLIAM R, SILVER JOEL B, HEISE CARLA C, MCBRIDE CHRISTOPHER, SHAFER CYNTHIA M, RENHOWE PAUL A, JANSEN JOHANNA M, NG SIMON, BARSANTI PAUL A, WAGMAN ALLAN S, MICHAJEWSKI TIMOTHY D, NI ZHI-JIE, BUSSIERE DIRKSEN, JAZAN ELISA, PECCHI SABINA, RAMURTHY SAVITHRI, PFISTER KEITH B, WIESMANN MARION
Format Patent
LanguageEnglish
Published 13.05.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
Bibliography:Application Number: US20030644055