Processes for preparing 7-carboxy substituted steroids

This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is -CH2- or wherein O-COR4 is in the alpha configuration; Z2 is -CH-; or Z1 and Z2 may be t...

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Bibliographic Details
Main Author MARIE WUTS PETER GUILLAUME
Format Patent
LanguageEnglish
Published 06.05.2004
Edition7
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is -CH2- or wherein O-COR4 is in the alpha configuration; Z2 is -CH-; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-alpha-epoxy-17-alpha-hydroxy-3-oxopregn-4-ene-alpha-7-21-dicarboxylic acid, gamma-lactone, methyl ester (eplerenone; epoxymexrenone).
Bibliography:Application Number: US20030392956