Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof

The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound rep...

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Main Authors NARA YOSHI, KURODA NORITAKA, HASHIGUCHI SHOHEI, KUSAKA MASAMI, YAMAOKA MASUO, TASAKA AKIHIRO, KAKU TOMOHIRO
Format Patent
LanguageEnglish
Published 15.04.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A and A is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A and A is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A , A and A is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.
Bibliography:Application Number: US20030433910