Novel indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof

According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R and R each stand for a hydrogen atom or an alkyl group, independently, or (ii...

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Main Authors YAMAMOTO YASUO, KASAI HIDENORI, TAKEYASU TAKUMI, YANAGISAWA YUMIKO, TAKENOUCHI OSAMI, SHIOKAWA SOJIRO, HARIYAMA KENZO
Format Patent
LanguageEnglish
Published 25.03.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R and R each stand for a hydrogen atom or an alkyl group, independently, or (ii) R and R as taken together form a cycloalkyl group or an aromatic ring, or (iii) R and R as taken together form a heterocyclic ring, and R is a hydrogen atom, a (C1-C10)alkyl group or others, R is a substituted alkyl group and R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.
Bibliography:Application Number: US20030275111