1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders

A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein each of R , R and R is independently selected from hydrido, alkyl, alkoxy, cyano, halo, hydro...

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Bibliographic Details
Main Authors MANNING ROBERT E, REITZ DAVID B
Format Patent
LanguageEnglish
Published 11.03.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein each of R , R and R is independently selected from hydrido, alkyl, alkoxy, cyano, halo, hydroxy, carboxyl, alkoxycarbonyl, formyl and acetyl; alkylcarbonyl and haloalkylcarbonyl; with the proviso that at least one of R , R and R must be a substituent other than hydrido, and with the further proviso that when each of R and R is hydrido, then R cannot be chloro; wherein R is hydrido; wherein R is alkyl; and wherein R is tetrazolyl; or a stereoisomer or a tautomer thereof or a pharmaceutically-acceptable salt thereof. These compounds are particularly useful in treatment or control of hypertension and congestive heart failure.
Bibliography:Application Number: US20030649210