Novel proteins and nucleic acids encoding same

• Main Authors: JI WEIZHEN, VERNET CORINE A.M, TCHERNEV VELIZAR T, BURGESS CATHERINE E, FERNANDES ELMA R, GUO XIAOJIA SASHA, LI LI, SHENOY SURESH G, KEKUDA RAMESH, LEITE MARIO W, ZHONG HAIHONG, LIU YI, GANGOLLI ESHA A, GORMAN LINDA, SPYTEK KIMBERLY A, GUSEV VLADIMIR Y, LEPLEY DENISE M, ANDERSON DAVID W, MALYANKAR URIEL M, CASMAN STACIE J, RIEGER DANIEL K, TAUPIER RAYMOND J, ZERHUSEN BRYAN D, PADIGARU MURALIDHARA, MILLER CHARLES E, GERLACH VALERIE, CATTERTON ELINA, PATTURAJAN MEERA, PENA CAROL E. A, ALSOBROOK JOHN P, SPADERNA STEVEN K
• Format: Patent
• Language: English
• Published: 04.03.2004
• Edition: 7
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.