Novel proteins and nucleic acids encoding same

• Main Authors: JI WEIZHEN, VERNET CORINE A.M, BURGESS CATHERINE E, ORT TATIANA, CHANT JOHN S, BERGHS CONSTANCE, GIOT LOIC, SHIMKETS RICHARD A, DIPIPPO VINCENT A, BOLDOG FERENC L, GUO XIAOJIA SASHA, LI LI, VOSS EDWARD Z, SHENOY SURESH G, EDINGER SHLOMIT R, KEKUDA RAMESH, ZHONG MEI, LEITE MARIO W, LIU XIAOHONG, RASTELLI LUCA, GANGOLLI ESHA A, OOI CHEAN ENG, GORMAN LINDA, ROTHENBERG MARK E, PENA CAROL E.A, SPYTEK KIMBERLY A, HJALT TORD, ANDERSON DAVID W, SMITHSON GLENNDA, RIEGER DANIEL K, CASMAN STACIE J, ELLERMAN KAREN, TAUPIER RAYMOND J, ZERHUSEN BRYAN D, EISEN ANDREW J, MILLER CHARLES E, PADIGARU MURALIDHARA, GERLACH VALERIE, CHAUDHURI AMITABHA, CATTERTON ELINA, PATTURAJAN MEERA, AGEE MICHELE L, KHRAMTSOV NIKOLAI V, SPADERNA STEVEN K
• Format: Patent
• Language: English
• Published: 22.01.2004
• Edition: 7
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.