Pharmaceutical compositions comprising proton pump inhibitors and gastrin/cholecystokinin receptor ligands

• Main Authors: HULL ROBERT ANTHONY DAVID, KALINDJIAN SARKIS BARRET, SHANKLEY NIGEL PAUL, ANDRIES LUC JOSEPH, MESENS JEAN LOUIS, BLACK JAMES WHYTE
• Format: Patent
• Language: English
• Published: 16.10.2003
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pharmaceutical compositions comprising a proton pump inhibitor and a compound of the formula (I) or its pharmaceutically acceptable salts, are useful in treating gastrointestinal disorders. X and Y are independently =N-, -N(R5>)- (R5 >being selected from H, Me, Et, Pr, Bn, -OH and -CH2 COOR6>, wherein R6 >represents H, Me, Et, Pr or Bn), =CH-, S- or -O-; n is from 1 to 4; R1 >is H or C1 to C15 hydrocarbyl wherein up to three C atoms may optionally be replaced by N, O and/or S atoms and up to three H atoms may optionally be replaced by halogen atoms; R2 >is selected from H, Me, Et, Pr and OH, each R2 >being independently selected from H, Me, Et, Pr and OH when n is greater than 1; R3 >(when n is 1) is selected from H, Me, Et and Pr; or (when n is greater than 1) each R3 >is independently selected from H, Me, Et, and Pr, or two R3 >groups on neighbouring carbon atoms which are linked by a double bond; or R2 >and R3 >on the same carbon atom are linked to form a C3 to C6 carbocylic ring, or two R3 groups are absent from neighbouring carbon atoms which are linked by a double bond; or R2 >and R3 >on the same carbon atom together represent an =O group; R4 >is C1 to C15 hydrocarbyl wherein up to two C atoms may optionally be replaced by N, O and/or S atoms and up to two H atoms may optionally be replaced by halogen atoms; Z is -(NR7>)a -CO-(NR8>)b - (wherein a is 0 or 1, b is 0 or 1, and R7 >and R8 >are independently selected from the groups recited above for R6>), -CO-NR7>-CH2 -CO-NR8>-, -CO-O-, -CH2 -CH2 -, -CH=CH-, -CH2 -NR- or a bond; Q is -R9>V, or (II) (wherein R9 >is -CH2 -; -CH2 -CH2 -; or (III) R9 >and R8>, together with the nitrogen atom to which R8 >is attached, form a piperidine or pyrrolid