Pyrrole derivatives

Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W is -CO-, -SO2-, an optionally substituted C1-C4 alkylene, etc.; Ar is an optionally substituted aryl, etc.; W and Ar mean the following (1) and (2): (1) W is an optionally subs...

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Bibliographic Details
Main Authors KITOH MAKOTO, HUME WILLIAM EWAN, TOKUNAGA TERUHISA, NAGATA RYU
Format Patent
LanguageEnglish
Published 25.09.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W is -CO-, -SO2-, an optionally substituted C1-C4 alkylene, etc.; Ar is an optionally substituted aryl, etc.; W and Ar mean the following (1) and (2): (1) W is an optionally substituted C1-C4 alkylene, etc.; Ar is an optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W is an optionally substituted C2-C5 alkylene, an optionally substituted C2-C5 alkenylene, etc.; and Ar is an aryl or monocyclic heteroaryl, which are substituted by carboxyl, an alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W , or a pharmaceutically acceptable salt thereof These compounds are useful as medicaments such as a fibrosis inhibitor for organs or tissues.
Bibliography:Application Number: US20030352067