Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development

The metabolic processes involved in the formation of any glucose-based metabolite are determined. A precursor molecule is labeled with a stable carbon ( C) isotope at specific positions. The label is allowed to distribute and rearrange in the system. Metabolites are recovered and analyzed against a...

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Bibliographic Details
Main Authors BOROS LASZLO G, LEE WAI-NANG PAUL
Format Patent
LanguageEnglish
Published 25.09.2003
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The metabolic processes involved in the formation of any glucose-based metabolite are determined. A precursor molecule is labeled with a stable carbon ( C) isotope at specific positions. The label is allowed to distribute and rearrange in the system. Metabolites are recovered and analyzed against a control system to determine metabolic pathway substrate flux caused by changes to the test system relative to the control system such as the addition of compound being tested as a potential drug.
Bibliography:Application Number: US20020192744