METHODS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION

The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of the Ca2+-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases ch...

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Main Authors MOUSSA ADEL M, SUN MINGHUA, HALPERIN JOSE, KELLEHER EUGENE W, FROIMOWITZ MARK, TAFT HEATHER N, LOMBARDY RICHARD JOHN, GAO YING-DUO, BELLOT JR EMILE M, KHER FALGUNI M, BRUGNARA CARLO, CLIFFORD JOHN J, SACHDEVA YESH P, HAIDER REEM M
Format Patent
LanguageEnglish
Published 17.07.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of the Ca2+-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.
Bibliography:Application Number: US19980159337