Stereoselective transacetalization of steroidal C-22 acetonide

The present invention is a process for the preparation of rofleponide of formula (II) where the 22R/22S ratio is 90/10 or greater which comprises contacting an acetonide of formula (I) with CH3-CH2-CH2-CHO (III) in the presence of perchloric acid where the concentration of the acetonide (I) is from...

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Bibliographic Details
Main Authors STANCHINA COREY L, REEDER LISA M
Format Patent
LanguageEnglish
Published 08.05.2003
Edition7
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The present invention is a process for the preparation of rofleponide of formula (II) where the 22R/22S ratio is 90/10 or greater which comprises contacting an acetonide of formula (I) with CH3-CH2-CH2-CHO (III) in the presence of perchloric acid where the concentration of the acetonide (I) is from about 1 g/20 ml to about 1 g/50 ml in the absence of an inert material.
Bibliography:Application Number: US20020247246