Calcineurin-related transgenic mammals, compositions and methods

The present invention provides a transgenic nonhuman mammal and mammalian cells whose genomes encode a calcineurin inhibitor. The expression of the inhibitor is targeted to the forebrain and may be induced experimentally. The present invention further provides a composition of matter comprising the...

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Bibliographic Details
Main Authors MANSUY ISABELLE, KANDEL ERIC R
Format Patent
LanguageEnglish
Published 14.11.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides a transgenic nonhuman mammal and mammalian cells whose genomes encode a calcineurin inhibitor. The expression of the inhibitor is targeted to the forebrain and may be induced experimentally. The present invention further provides a composition of matter comprising the nucleic acid sequences encoding the inhibitor and additional sequences required for its targeted expression and regulation. In addition, the present invention provides methods for determining whether an agent inhibits long-term potentiation and/or learning and memory in a mammal.
Bibliography:Application Number: US20020091714