Process for the preparation of macrocyclic metalloprotease inhibitors
The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland Claisen rearrangement of a...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
31.01.2002
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to processes for the preparation of macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland Claisen rearrangement of a silyl ketene acetal which proceeds with high stereoselectivity. |
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Bibliography: | Application Number: US20010919564 |